Access DTP’s Resources to Advance Your Therapeutic Candidate to the Clinic

DTP provides grants, services, and resources to the extramural community to facilitate the discovery and development of new cancer therapeutic agents.

DTP’s drug discovery and development services cover the critical path of steps needed to carry R&D programs from drug discovery through preclinical development and IND-enabling studies to support first-in-human trials.

• NCI-60 Human Tumor Cell Lines Screens — Unique cell killing dose response screens across 60 human tumor cell lines allowing response patterns to be analyzed by algorithms (COMPARE)
• Stepping Stones Program — Discrete drug development studies for grantees
• Consultation Service — Helps innovators to meet standards required for early-phase clinical trials via NCI’s Experimental Therapeutics (NExT) Program
• Repositories — Tumors, cell lines, patient-derived models, chemicals, natural products, and biological reagents
• Databases & Tools — Includes data search tools, bulk data download, COMPARE analysis, NCI-ALMANAC, and ROADMAPS datasets
• Open Funding Opportunities — Notices of Funding Opportunities involving DTP initiatives plus DTP staff contacts
• Drug Discovery/Development — Proof-of-concept studies in vitro and in vivo and support for product development through all phases of the critical path toward clinical use from medicinal chemistry through safety testing and cGMP manufacturing including:
  • Small Molecules
    • Synthesis
    • Toxicology
  • Biologics
    • Peptides, retroviral & lentiviral vectors, viral & DNA vaccines, gene therapy products, CAR T-cell products
    • Immunologics
  • Natural products
• Additional Resources

  • Helping Extramural Innovators Reach the Clinic: NCI Developmental Therapeutics Program; Slides from DTP’s NCI-sponsored session at AACR 2023

    Click here to download slides.

  • NCI Drug Development Workshop: How to Advance a Therapeutic Candidate from Bench to Bedside; Nine webinar recordings from the 2021 webinar series
  • NCI Drug Development Workshop II: Specialized Topics in Preclinical Development of Small Molecule Cancer Drugs
    • Starting at 1:00 PM ET on three sets of Thursdays and Fridays from June 22 to July 28, 2023
    • Format: 60 - 90 minutes of virtual lectures followed by 15 minutes of Q&A

Contact DTP staff (dtpinfo@mail.nih.gov) with questions about how we can assist you with your research.