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Developmental Therapeutics Program (DTP)

Stage2 tested compounds that inhibit the growth of the CLN2 overexpressing strain

Inhibited Strains

NSC/name 1.2 microM 3.7 microM 11 microM 33 microM 100 microM Stage2 Graphs NCI 60 Human
Tumor Cell Data
3D Structure
of Compound
Basic Chemical Data
180198
HYDRAZINECARBOTHIOAMIDE,
2,2'-(1,5-DIMETHYL-1,5-PENTANE
DIYLIDENE)BIS[N-METHYL-
CLN2oe CLN2oe CLN2oe rad50 wt2 CLN2oe bub3 rad50 wt2 CLN2oe bub3 rad50 Stage2 Graphs for 180198   3D Structure for 180198 Basic Chemical Data for 180198
659206 CLN2oe CLN2oe CLN2oe bub3 mec2 rad14 rad18 rad52 mgt1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 659206 60 Cell Data for 659206 3D Structure for 659206 Basic Chemical Data for 659206
83436
ERIOSTEMOIC ACID
      CLN2oe CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 83436 60 Cell Data for 83436 3D Structure for 83436 Basic Chemical Data for 83436
89457         CLN2oe Stage2 Graphs for 89457 60 Cell Data for 89457 3D Structure for 89457 Basic Chemical Data for 89457
339124         CLN2oe Stage2 Graphs for 339124 60 Cell Data for 339124 3D Structure for 339124 Basic Chemical Data for 339124
363003       CLN2oe CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 363003 60 Cell Data for 363003 3D Structure for 363003 Basic Chemical Data for 363003
381804   CLN2oe all all all Stage2 Graphs for 381804 60 Cell Data for 381804   Basic Chemical Data for 381804
401360
LYCORINE
    CLN2oe CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 401360   3D Structure for 401360 Basic Chemical Data for 401360
647140         CLN2oe Stage2 Graphs for 647140 60 Cell Data for 647140 3D Structure for 647140 Basic Chemical Data for 647140
665515       CLN2oe CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 665515 60 Cell Data for 665515 3D Structure for 665515 Basic Chemical Data for 665515
7962       CLN2oe mec2 CLN2oe bub3 mec2 rad14 rad50 mgt1 mlh1 Stage2 Graphs for 7962 60 Cell Data for 7962 3D Structure for 7962 Basic Chemical Data for 7962
55844       CLN2oe bub3 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 55844   3D Structure for 55844 Basic Chemical Data for 55844
58308
BENZOIN, 4,4'-DICHLORO-
        CLN2oe bub3 Stage2 Graphs for 58308   3D Structure for 58308 Basic Chemical Data for 58308
160879
LUTEOSKYRIN
    CLN2oe mec2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 160879 60 Cell Data for 160879 3D Structure for 160879 Basic Chemical Data for 160879
201680   CLN2oe sgs1 CLN2oe bub3 mec2 rad18 rad50 rad52 wt1 mgt1 mlh1 rad50EPP+ sgs1 wt2 all all Stage2 Graphs for 201680 60 Cell Data for 201680 3D Structure for 201680 Basic Chemical Data for 201680
254304
PHENOL, 4,4'-METHYLENEBIS
[2-[(PROPYLIMINO)METHYL]-
CLN2oe mec2 all all all all Stage2 Graphs for 254304 60 Cell Data for 254304 3D Structure for 254304 Basic Chemical Data for 254304
401518       CLN2oe rad52 all Stage2 Graphs for 401518   3D Structure for 401518 Basic Chemical Data for 401518
408301         CLN2oe rad50 rad52 Stage2 Graphs for 408301 60 Cell Data for 408301 3D Structure for 408301 Basic Chemical Data for 408301
622124     rad50EPP+ CLN2oe rad50 rad52 rad50EPP+ CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 622124 60 Cell Data for 622124   Basic Chemical Data for 622124
670965         CLN2oe rad14 Stage2 Graphs for 670965 60 Cell Data for 670965 3D Structure for 670965 Basic Chemical Data for 670965
686380       CLN2oe mec2 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 686380 60 Cell Data for 686380 3D Structure for 686380 Basic Chemical Data for 686380
330507
GELDANAMYCIN, 17-ALLYL
AMINO-17-DEMETHOXY-
    CLN2oe bub3 mec2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 330507 60 Cell Data for 330507   Basic Chemical Data for 330507
403126         CLN2oe rad18 rad50 rad52 Stage2 Graphs for 403126   3D Structure for 403126 Basic Chemical Data for 403126
639176
(S)9-AMINO-20-O-(N,N-DIMETHYL)
GLYCINYL CAMPTOTHECIN.HCL
  rad50 rad52 rad50 rad52 mec2 rad50 rad52 rad50EPP+ CLN2oe mec2 rad50 rad52 rad50EPP+ Stage2 Graphs for 639176   3D Structure for 639176 Basic Chemical Data for 639176
642481 rad14 CLN2oe rad14 mgt1 CLN2oe rad14 mgt1 wt2 CLN2oe bub3 mec2 rad14 rad50 rad52 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 642481 60 Cell Data for 642481 3D Structure for 642481 Basic Chemical Data for 642481
666398     CLN2oe rad18 rad50 rad52 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 sgs1 wt2 CLN2oe mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 666398 60 Cell Data for 666398 3D Structure for 666398 Basic Chemical Data for 666398
669160
1-AZIDO-2-(2-PYRIDYL)-
PHENALEN-3-ONE
      rad50EPP+ CLN2oe rad18 rad50 rad52 rad50EPP+ Stage2 Graphs for 669160 60 Cell Data for 669160 3D Structure for 669160 Basic Chemical Data for 669160
669965 rad50 rad52 rad50EPP+ rad50 rad52 rad50EPP+ rad50 rad52 rad50EPP+ rad50 rad52 rad50EPP+ CLN2oe rad18 rad50 rad52 rad50EPP+ Stage2 Graphs for 669965 60 Cell Data for 669965 3D Structure for 669965 Basic Chemical Data for 669965
678914
4-ACRIDINECARBOXAMIDE, N-
[2-(DIMETHYLAMINO)ETHYL]- 1-
METHOXY-, DIHYDROCHLORIDE
  rad50 rad50 rad52 rad50 rad52 rad50EPP+ CLN2oe mec2 rad50 rad52 mlh1 rad50EPP+ wt2 Stage2 Graphs for 678914 60 Cell Data for 678914 3D Structure for 678914 Basic Chemical Data for 678914
683414   rad50 rad52 rad50 rad52 rad50 rad52 CLN2oe mec2 rad50 rad52 Stage2 Graphs for 683414 60 Cell Data for 683414 3D Structure for 683414 Basic Chemical Data for 683414
59954
DEHYDROABIETIC ACID
    CLN2oe bub3 mec2 rad50 rad52 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 59954   3D Structure for 59954 Basic Chemical Data for 59954
59989
O-BENZYL-P-CHLOROPHENOL
    CLN2oe bub3 mec2 mgt1 all all Stage2 Graphs for 59989   3D Structure for 59989 Basic Chemical Data for 59989
96914
DECAFLUOROBENZOPHENONE
  CLN2oe bub3 mec2 sgs1 all all all Stage2 Graphs for 96914 60 Cell Data for 96914 3D Structure for 96914 Basic Chemical Data for 96914
286699     rad18 rad50EPP+ CLN2oe bub3 rad18 rad50 rad52 rad50EPP+ bub3 rad18 rad50 rad52 rad50EPP+ Stage2 Graphs for 286699   3D Structure for 286699 Basic Chemical Data for 286699
610456
CAMPTOTHECIN HEMISUCCINATE
SODIUM SALT
rad50 rad52 rad50 rad52 rad50 rad52 rad50EPP+ CLN2oe mec2 rad50 rad52 rad50EPP+ sgs1 all Stage2 Graphs for 610456 60 Cell Data for 610456 3D Structure for 610456 Basic Chemical Data for 610456
622677   CLN2oe rad14 mlh1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 all all Stage2 Graphs for 622677 60 Cell Data for 622677 3D Structure for 622677 Basic Chemical Data for 622677
658900   rad18 CLN2oe rad18 rad50EPP+ CLN2oe bub3 rad18 rad50 rad50EPP+ CLN2oe bub3 rad18 rad50 rad50EPP+ Stage2 Graphs for 658900 60 Cell Data for 658900 3D Structure for 658900 Basic Chemical Data for 658900
665773       CLN2oe rad14 mgt1 sgs1 CLN2oe rad14 mgt1 sgs1 Stage2 Graphs for 665773 60 Cell Data for 665773 3D Structure for 665773 Basic Chemical Data for 665773
668840   CLN2oe mec2 rad18 rad50 rad52 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 668840 60 Cell Data for 668840 3D Structure for 668840 Basic Chemical Data for 668840
684839     CLN2oe bub3 mec2 rad52 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 684839 60 Cell Data for 684839 3D Structure for 684839 Basic Chemical Data for 684839
687355
1H-[1,2,4]TRIAZOLO[1,2-A]
PYRIDAZINE-8-CARBOXYLIC ACID,
5-[(2,3,4,6-O-TETRAACETYL-
BETA-D-GLUCOPYRAN
      wt2 CLN2oe bub3 rad18 rad52 sgs1 wt2 Stage2 Graphs for 687355 60 Cell Data for 687355 3D Structure for 687355 Basic Chemical Data for 687355