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Developmental Therapeutics Program (DTP)

Stage2 tested compounds that inhibit the growth of the mgt1 mutant strain

Inhibited Strains

NSC/name 1.2 microM 3.7 microM 11 microM 33 microM 100 microM Stage2 Graphs NCI 60 Human
Tumor Cell Data
3D Structure
of Compound
Basic Chemical Data
5570
N-PHENYLTHIOUREIDOACETIC
ACID
      mgt1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 5570   3D Structure for 5570 Basic Chemical Data for 5570
63358       mgt1 CLN2oe bub3 mec2 rad14 rad50 rad52 wt1 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 63358 60 Cell Data for 63358 3D Structure for 63358 Basic Chemical Data for 63358
108212       mgt1 all Stage2 Graphs for 108212 60 Cell Data for 108212 3D Structure for 108212 Basic Chemical Data for 108212
158378         mgt1 Stage2 Graphs for 158378 60 Cell Data for 158378 3D Structure for 158378 Basic Chemical Data for 158378
408400         mgt1 Stage2 Graphs for 408400   3D Structure for 408400 Basic Chemical Data for 408400
605707
RUTHENATE(3-), AQUADICHLORO
[N,N'-1,2-CYCLOHEXANEDIYL
BIS [N-(CARBOXYMETHYL)
GLYCINATO](4-)-N,N',O(1)]-
      mgt1 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 605707     Basic Chemical Data for 605707
606752         mgt1 Stage2 Graphs for 606752   3D Structure for 606752 Basic Chemical Data for 606752
641298     mgt1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 all Stage2 Graphs for 641298 60 Cell Data for 641298 3D Structure for 641298 Basic Chemical Data for 641298
665371     mgt1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 665371 60 Cell Data for 665371 3D Structure for 665371 Basic Chemical Data for 665371
683828     mgt1 bub3 rad14 mgt1 mlh1 wt2 bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 683828 60 Cell Data for 683828 3D Structure for 683828 Basic Chemical Data for 683828
6312
1H-INDENE-1,3(2H)-DIONE
        rad18 mgt1 Stage2 Graphs for 6312   3D Structure for 6312 Basic Chemical Data for 6312
11226
TOLUYLENE BLUE
(BIOLOGICAL STAIN)
        bub3 rad14 rad50 rad52 wt1 mgt1 Stage2 Graphs for 11226   3D Structure for 11226 Basic Chemical Data for 11226
87596
3-(P-HYDROXYANILINOMETHYL
-BENZOTHIAZOLINE-2-THIONE
HYDROCHLORIDE
      mec2 mgt1 all Stage2 Graphs for 87596 60 Cell Data for 87596 3D Structure for 87596 Basic Chemical Data for 87596
127922       mgt1 rad50EPP+ bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 127922 60 Cell Data for 127922 3D Structure for 127922 Basic Chemical Data for 127922
138367       rad14 mgt1 all Stage2 Graphs for 138367 60 Cell Data for 138367 3D Structure for 138367 Basic Chemical Data for 138367
163482       rad50 rad52 mgt1 all Stage2 Graphs for 163482 60 Cell Data for 163482   Basic Chemical Data for 163482
170984
1-[1-[4,4-BIS(P-FLUOROPHENYL)
BUTYL]-4-PIPERIDYL]-2-
BENZIMIDAZOLINONE
        rad14 mgt1 Stage2 Graphs for 170984 60 Cell Data for 170984   Basic Chemical Data for 170984
176371         rad50 mgt1 rad50EPP+ Stage2 Graphs for 176371   3D Structure for 176371 Basic Chemical Data for 176371
176410         mgt1 sgs1 Stage2 Graphs for 176410 60 Cell Data for 176410 3D Structure for 176410 Basic Chemical Data for 176410
268617
BENZENAMINE, 4-[2-(7,8-
DIMETHYL-4-QUINOLINYL)ETHENYL]-
N,N-DIMETHYL-
      mgt1 sgs1 CLN2oe bub3 rad14 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 268617 60 Cell Data for 268617 3D Structure for 268617 Basic Chemical Data for 268617
290779         mgt1 sgs1 Stage2 Graphs for 290779   3D Structure for 290779 Basic Chemical Data for 290779
290959         mgt1 sgs1 Stage2 Graphs for 290959   3D Structure for 290959 Basic Chemical Data for 290959
306424
4-MORPHOLINAMINE, 3-METHYL
-N-(1-METHYL-2-PHENYLETHYL)
-2-PHENYL-, MONOHYDROCHLORIDE
      mgt1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 306424   3D Structure for 306424 Basic Chemical Data for 306424
308811   rad14 mgt1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 all all Stage2 Graphs for 308811 60 Cell Data for 308811 3D Structure for 308811 Basic Chemical Data for 308811
339606       rad18 mgt1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 339606 60 Cell Data for 339606 3D Structure for 339606 Basic Chemical Data for 339606
510656
BENZONITRILE, 2-AMINO-3,5-DINITRO
      rad14 rad14 rad50 rad52 wt1 mgt1 mlh1 Stage2 Graphs for 510656 60 Cell Data for 510656 3D Structure for 510656 Basic Chemical Data for 510656
628343
1,2,4-TRIAZINE-3,5(2H,4H)
DITHIONE, 6-BENZYL-
    mgt1 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 628343 60 Cell Data for 628343 3D Structure for 628343 Basic Chemical Data for 628343
630456       mgt1 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 630456 60 Cell Data for 630456 3D Structure for 630456 Basic Chemical Data for 630456
640536   mec2 wt1 mgt1 rad50EPP+ all all all Stage2 Graphs for 640536   3D Structure for 640536 Basic Chemical Data for 640536
644607     rad14 mgt1 all all Stage2 Graphs for 644607 60 Cell Data for 644607 3D Structure for 644607 Basic Chemical Data for 644607
663857
ACETAMIDE, 2,2'-DICYCLOHEXYL
-N-[7-(HEXAHYDRO- 1(2H)-
AZOCINYL)HEPTYL]-, HYDROCHLORIDE
rad14 rad14 mgt1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 663857 60 Cell Data for 663857 3D Structure for 663857 Basic Chemical Data for 663857
675583         mgt1 sgs1 Stage2 Graphs for 675583 60 Cell Data for 675583 3D Structure for 675583 Basic Chemical Data for 675583
13162       rad14 rad50 rad14 rad50 wt1 mgt1 mlh1 rad50EPP+ Stage2 Graphs for 13162 60 Cell Data for 13162   Basic Chemical Data for 13162
90862       bub3 rad18 mgt1 bub3 mec2 rad14 rad18 rad50 mgt1 Stage2 Graphs for 90862 60 Cell Data for 90862 3D Structure for 90862 Basic Chemical Data for 90862
129925     rad14 mgt1 sgs1 all all Stage2 Graphs for 129925   3D Structure for 129925 Basic Chemical Data for 129925
140399         rad18 mgt1 sgs1 Stage2 Graphs for 140399   3D Structure for 140399 Basic Chemical Data for 140399
142480     mgt1 mlh1 rad50EPP+ all all Stage2 Graphs for 142480   3D Structure for 142480 Basic Chemical Data for 142480
251757
2-CHLORO-6-(4-CHLOROPHENYL
)-2,5-CYCLOHEXADIENE-1,4-DIONE
    mgt1 mlh1 rad50EPP+ all all Stage2 Graphs for 251757 60 Cell Data for 251757 3D Structure for 251757 Basic Chemical Data for 251757
290977   mgt1 mlh1 sgs1 all all all Stage2 Graphs for 290977   3D Structure for 290977 Basic Chemical Data for 290977
290980   mgt1 mlh1 sgs1 all all all Stage2 Graphs for 290980   3D Structure for 290980 Basic Chemical Data for 290980
295085
5H-BENZOCYCLOHEPTEN-5-
ONE, 6,6-DIBROMO-6,7,8,9-TETRA
HYDRO-2-METHOXY-3-NITRO-
  mgt1 mlh1 rad50EPP+ bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 rad50EPP+ sgs1 wt2 all all Stage2 Graphs for 295085   3D Structure for 295085 Basic Chemical Data for 295085
295563
2-BUTENOIC ACID, 2,3-DIBROMO
-4-[[(4-METHYLPHENYL)SULFONYL]
HYDRAZONO]-, (Z)-
    rad50 rad52 mgt1 mlh1 rad50EPP+ bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 rad50EPP+ sgs1 wt2 bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 295563 60 Cell Data for 295563 3D Structure for 295563 Basic Chemical Data for 295563
297093
1,3-DIOXANE-4,6-DIONE, 2,2-
DIMETHYL-5-[(5-NITRO-2-THIENYL)
METHYLENE]-
      rad18 mgt1 rad50EPP+ CLN2oe rad14 rad50 rad52 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 297093 60 Cell Data for 297093 3D Structure for 297093 Basic Chemical Data for 297093
400987     mgt1 rad50EPP+ sgs1 mgt1 mlh1 rad50EPP+ sgs1 wt2 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 400987   3D Structure for 400987 Basic Chemical Data for 400987
400995       rad14 mgt1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 400995 60 Cell Data for 400995 3D Structure for 400995 Basic Chemical Data for 400995
402700         mgt1 mlh1 sgs1 Stage2 Graphs for 402700   3D Structure for 402700 Basic Chemical Data for 402700
402756
1-METHOXYPHENAZINE
      rad18 rad50 rad52 mgt1 rad50EPP+ all Stage2 Graphs for 402756 60 Cell Data for 402756 3D Structure for 402756 Basic Chemical Data for 402756
634502   rad14 mgt1 mlh1 all all all Stage2 Graphs for 634502 60 Cell Data for 634502 3D Structure for 634502 Basic Chemical Data for 634502
637826     bub3 mgt1 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 all Stage2 Graphs for 637826 60 Cell Data for 637826 3D Structure for 637826 Basic Chemical Data for 637826
642481 rad14 CLN2oe rad14 mgt1 CLN2oe rad14 mgt1 wt2 CLN2oe bub3 mec2 rad14 rad50 rad52 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 642481 60 Cell Data for 642481 3D Structure for 642481 Basic Chemical Data for 642481
658336     rad18 rad18 sgs1 rad18 mgt1 rad50EPP+ Stage2 Graphs for 658336 60 Cell Data for 658336 3D Structure for 658336 Basic Chemical Data for 658336
665370       rad14 mgt1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 665370 60 Cell Data for 665370 3D Structure for 665370 Basic Chemical Data for 665370
672453         rad14 mgt1 mlh1 Stage2 Graphs for 672453 60 Cell Data for 672453 3D Structure for 672453 Basic Chemical Data for 672453
684405
1-(4'-PHTHALIMIDOPROPYL-
CARBONYL)-5-FLUOROURACIL
      mec2 mgt1 sgs1 mec2 rad50 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 684405 60 Cell Data for 684405 3D Structure for 684405 Basic Chemical Data for 684405
19893
5-FLUOROURACIL
    mgt1 mlh1 rad50EPP+ sgs1 mec2 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 wt2 bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 19893 60 Cell Data for 19893 3D Structure for 19893 Basic Chemical Data for 19893
59989
O-BENZYL-P-CHLOROPHENOL
    CLN2oe bub3 mec2 mgt1 all all Stage2 Graphs for 59989   3D Structure for 59989 Basic Chemical Data for 59989
63300         rad14 rad18 mgt1 sgs1 Stage2 Graphs for 63300   3D Structure for 63300 Basic Chemical Data for 63300
92835         bub3 mec2 mgt1 sgs1 Stage2 Graphs for 92835 60 Cell Data for 92835 3D Structure for 92835 Basic Chemical Data for 92835
93846         bub3 rad50 mgt1 rad50EPP+ sgs1 Stage2 Graphs for 93846 60 Cell Data for 93846 3D Structure for 93846 Basic Chemical Data for 93846
135880   bub3 mec2 mgt1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 all all Stage2 Graphs for 135880   3D Structure for 135880 Basic Chemical Data for 135880
137044       rad50EPP+ bub3 rad18 rad52 mgt1 rad50EPP+ Stage2 Graphs for 137044   3D Structure for 137044 Basic Chemical Data for 137044
141103         rad14 rad18 mgt1 sgs1 Stage2 Graphs for 141103   3D Structure for 141103 Basic Chemical Data for 141103
142496       bub3 rad14 mgt1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 142496 60 Cell Data for 142496 3D Structure for 142496 Basic Chemical Data for 142496
142626         rad14 rad18 mgt1 sgs1 Stage2 Graphs for 142626   3D Structure for 142626 Basic Chemical Data for 142626
290721         mgt1 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 290721   3D Structure for 290721 Basic Chemical Data for 290721
290963   rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 all all all Stage2 Graphs for 290963   3D Structure for 290963 Basic Chemical Data for 290963
290979   rad50 mgt1 mlh1 rad50EPP+ sgs1 all all all Stage2 Graphs for 290979   3D Structure for 290979 Basic Chemical Data for 290979
328085   rad50EPP+ rad14 mgt1 rad50EPP+ sgs1 all all Stage2 Graphs for 328085   3D Structure for 328085 Basic Chemical Data for 328085
371189       bub3 rad18 mgt1 rad50EPP+ bub3 mec2 rad14 rad18 rad50 mgt1 mlh1 rad50EPP+ Stage2 Graphs for 371189 60 Cell Data for 371189   Basic Chemical Data for 371189
382936       rad14 rad18 mgt1 sgs1 bub3 mec2 rad14 rad18 rad50 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 382936 60 Cell Data for 382936   Basic Chemical Data for 382936
401166       bub3 rad18 rad50 mgt1 bub3 rad18 rad50 rad52 mgt1 mlh1 sgs1 Stage2 Graphs for 401166 60 Cell Data for 401166 3D Structure for 401166 Basic Chemical Data for 401166
409425
1,6-DIMETHYL-1,6-DINITROSO
BIUREA
rad18 rad18 rad18 rad18 rad50 rad52 mgt1 rad50EPP+ sgs1 mec2 rad18 rad50 rad52 mgt1 rad50EPP+ sgs1 Stage2 Graphs for 409425 60 Cell Data for 409425 3D Structure for 409425 Basic Chemical Data for 409425
611360
PREPACIFENNOL EPOXIDE
      rad18 rad50 mgt1 sgs1 all Stage2 Graphs for 611360   3D Structure for 611360 Basic Chemical Data for 611360
645843     rad14 mgt1 mlh1 sgs1 bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 sgs1 wt2 all Stage2 Graphs for 645843 60 Cell Data for 645843 3D Structure for 645843 Basic Chemical Data for 645843
658139
9H-FLUOREN-9-ONE, 2,4,7-TRI
NITRO-, (9,10-DIHYDROANTHRACEN
- 9-YLIDENE)HYDRAZONE
  mec2 rad18 mgt1 rad50EPP+ all all all Stage2 Graphs for 658139 60 Cell Data for 658139 3D Structure for 658139 Basic Chemical Data for 658139
661224       rad50EPP+ rad18 mgt1 mlh1 rad50EPP+ Stage2 Graphs for 661224 60 Cell Data for 661224 3D Structure for 661224 Basic Chemical Data for 661224
665773       CLN2oe rad14 mgt1 sgs1 CLN2oe rad14 mgt1 sgs1 Stage2 Graphs for 665773 60 Cell Data for 665773 3D Structure for 665773 Basic Chemical Data for 665773
668370
3,3-DIIODO-2-PHENYL-2-PROPENAL
rad50 rad52 rad50EPP+ rad50 rad52 rad50EPP+ rad14 rad18 rad50 rad52 mgt1 rad50EPP+ all all Stage2 Graphs for 668370 60 Cell Data for 668370 3D Structure for 668370 Basic Chemical Data for 668370
669264     rad50 sgs1 rad50 sgs1 rad50 mgt1 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 669264 60 Cell Data for 669264 3D Structure for 669264 Basic Chemical Data for 669264
670225
CIS-2((1-(4-METHYL-PHENYL)
METHYL)-4-TERT.BUTYLCYCLOHEXYL)
OXYN,N-DIMETHYL-1-
ETHANAMINE-,SALT WITH FUM
      rad14 mgt1 mlh1 sgs1 all Stage2 Graphs for 670225 60 Cell Data for 670225 3D Structure for 670225 Basic Chemical Data for 670225
674352
3,6-DIMETHYLTHIO-1,2,4,5-
TETRAZINE
      bub3 mec2 rad14 mgt1 all Stage2 Graphs for 674352   3D Structure for 674352 Basic Chemical Data for 674352
674560         bub3 rad14 mgt1 mlh1 Stage2 Graphs for 674560 60 Cell Data for 674560 3D Structure for 674560 Basic Chemical Data for 674560