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Developmental Therapeutics Program (DTP)

Stage2 tested compounds that inhibit the growth of the mlh1 mutant strain

Inhibited Strains

NSC/name 1.2 microM 3.7 microM 11 microM 33 microM 100 microM Stage2 Graphs NCI 60 Human
Tumor Cell Data
3D Structure
of Compound
Basic Chemical Data
290718       mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 290718   3D Structure for 290718 Basic Chemical Data for 290718
290981   mlh1 all all all Stage2 Graphs for 290981   3D Structure for 290981 Basic Chemical Data for 290981
403018         mlh1 Stage2 Graphs for 403018 60 Cell Data for 403018 3D Structure for 403018 Basic Chemical Data for 403018
400655     mec2 mlh1 mec2 mlh1 mec2 mlh1 Stage2 Graphs for 400655   3D Structure for 400655 Basic Chemical Data for 400655
98141         rad18 mlh1 Stage2 Graphs for 98141   3D Structure for 98141 Basic Chemical Data for 98141
141138         rad50 mlh1 Stage2 Graphs for 141138   3D Structure for 141138 Basic Chemical Data for 141138
276361
1H-PYRROLE-3,4-DIMETHANOL,
1-(4-BUTYLPHENYL)-2,5-
DIMETHYL-, BIS(METHYLCARBAMATE)
(ESTER)
    rad14 mlh1 all all Stage2 Graphs for 276361 60 Cell Data for 276361 3D Structure for 276361 Basic Chemical Data for 276361
297353     rad50 rad52 wt1 mlh1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 all Stage2 Graphs for 297353   3D Structure for 297353 Basic Chemical Data for 297353
373814 mec2 mlh1 bub3 mec2 rad18 rad50 mlh1 rad50EPP+ sgs1 all all all Stage2 Graphs for 373814 60 Cell Data for 373814   Basic Chemical Data for 373814
404886   rad50 rad52 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 all all Stage2 Graphs for 404886 60 Cell Data for 404886 3D Structure for 404886 Basic Chemical Data for 404886
408726       rad50 rad52 mlh1 rad50EPP+ all Stage2 Graphs for 408726 60 Cell Data for 408726 3D Structure for 408726 Basic Chemical Data for 408726
510656
BENZONITRILE, 2-AMINO-3,5-DINITRO
      rad14 rad14 rad50 rad52 wt1 mgt1 mlh1 Stage2 Graphs for 510656 60 Cell Data for 510656 3D Structure for 510656 Basic Chemical Data for 510656
527017
AMPHOTERICIN B
  mlh1 rad50EPP+ all all all Stage2 Graphs for 527017 60 Cell Data for 527017 3D Structure for 527017 Basic Chemical Data for 527017
628343
1,2,4-TRIAZINE-3,5(2H,4H)
DITHIONE, 6-BENZYL-
    mgt1 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 628343 60 Cell Data for 628343 3D Structure for 628343 Basic Chemical Data for 628343
630456       mgt1 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 630456 60 Cell Data for 630456 3D Structure for 630456 Basic Chemical Data for 630456
643175
2-(3,4-DIMETHOXY
BENZYLIDENE)-1-TETRALONE
      bub3 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 643175 60 Cell Data for 643175 3D Structure for 643175 Basic Chemical Data for 643175
647408
BENZOIC ACID, 2-(AMINOSULFONYL)
-, 2-[[[1-METHYL- 2-(2-OXO-4-
HYDROXY-2H-1-BENZOPYRAN-3-
YL)(PHENYL)METHYL]- 3-(1-
PIPERIDINYL)PROPYL]HYDRAZONE, HYDROCHLORIDE
      bub3 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 wt1 mgt1 mlh1 sgs1 Stage2 Graphs for 647408 60 Cell Data for 647408 3D Structure for 647408 Basic Chemical Data for 647408
649905       rad14 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 649905 60 Cell Data for 649905 3D Structure for 649905 Basic Chemical Data for 649905
657149
2-ACETYL-1,2-DIHYDRO
ELLIPTICINE
  rad50 rad52 mlh1 rad50EPP+ all all all Stage2 Graphs for 657149 60 Cell Data for 657149 3D Structure for 657149 Basic Chemical Data for 657149
661440
5H-BENZOCYCLOHEPTEN-5-
ONE, 6,7,8,9-TETRAHYDRO-6-[(DI
METHYLAMINO)METHYL]-,
HYDROCHLORIDE
      mlh1 rad50EPP+ CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 661440 60 Cell Data for 661440 3D Structure for 661440 Basic Chemical Data for 661440
663333         rad50 mlh1 Stage2 Graphs for 663333 60 Cell Data for 663333 3D Structure for 663333 Basic Chemical Data for 663333
13162       rad14 rad50 rad14 rad50 wt1 mgt1 mlh1 rad50EPP+ Stage2 Graphs for 13162 60 Cell Data for 13162   Basic Chemical Data for 13162
13973
ACRIDINE YELLOW G
      mec2 rad50 rad52 mlh1 rad50EPP+ all Stage2 Graphs for 13973 60 Cell Data for 13973 3D Structure for 13973 Basic Chemical Data for 13973
96887       bub3 mlh1 rad50EPP+ all Stage2 Graphs for 96887 60 Cell Data for 96887   Basic Chemical Data for 96887
114016         rad18 mlh1 rad50EPP+ Stage2 Graphs for 114016   3D Structure for 114016 Basic Chemical Data for 114016
134662       rad18 mlh1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 134662   3D Structure for 134662 Basic Chemical Data for 134662
139727       rad50 rad52 mlh1 rad50EPP+ sgs1 all Stage2 Graphs for 139727   3D Structure for 139727 Basic Chemical Data for 139727
142480     mgt1 mlh1 rad50EPP+ all all Stage2 Graphs for 142480   3D Structure for 142480 Basic Chemical Data for 142480
176408       rad14 mlh1 sgs1 all Stage2 Graphs for 176408 60 Cell Data for 176408 3D Structure for 176408 Basic Chemical Data for 176408
251757
2-CHLORO-6-(4-CHLOROPHENYL
)-2,5-CYCLOHEXADIENE-1,4-DIONE
    mgt1 mlh1 rad50EPP+ all all Stage2 Graphs for 251757 60 Cell Data for 251757 3D Structure for 251757 Basic Chemical Data for 251757
290977   mgt1 mlh1 sgs1 all all all Stage2 Graphs for 290977   3D Structure for 290977 Basic Chemical Data for 290977
290980   mgt1 mlh1 sgs1 all all all Stage2 Graphs for 290980   3D Structure for 290980 Basic Chemical Data for 290980
295085
5H-BENZOCYCLOHEPTEN-5-
ONE, 6,6-DIBROMO-6,7,8,9-TETRA
HYDRO-2-METHOXY-3-NITRO-
  mgt1 mlh1 rad50EPP+ bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 rad50EPP+ sgs1 wt2 all all Stage2 Graphs for 295085   3D Structure for 295085 Basic Chemical Data for 295085
295563
2-BUTENOIC ACID, 2,3-DIBROMO
-4-[[(4-METHYLPHENYL)SULFONYL]
HYDRAZONO]-, (Z)-
    rad50 rad52 mgt1 mlh1 rad50EPP+ bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 rad50EPP+ sgs1 wt2 bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 295563 60 Cell Data for 295563 3D Structure for 295563 Basic Chemical Data for 295563
401158
2-ANTHRAQUINONE
CARBOXALDEHYDE
      rad50 rad52 rad50EPP+ rad18 rad50 rad52 mlh1 rad50EPP+ Stage2 Graphs for 401158   3D Structure for 401158 Basic Chemical Data for 401158
402700         mgt1 mlh1 sgs1 Stage2 Graphs for 402700   3D Structure for 402700 Basic Chemical Data for 402700
637826     bub3 mgt1 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 all Stage2 Graphs for 637826 60 Cell Data for 637826 3D Structure for 637826 Basic Chemical Data for 637826
644221       rad50 bub3 rad50 rad52 mlh1 Stage2 Graphs for 644221 60 Cell Data for 644221 3D Structure for 644221 Basic Chemical Data for 644221
658142
2-(1-(4-(2-PYRIDYL)PIPERAZINO))
NAPHTHAZARIN
        rad14 mlh1 sgs1 Stage2 Graphs for 658142 60 Cell Data for 658142 3D Structure for 658142 Basic Chemical Data for 658142
663623     bub3 mlh1 sgs1 all all Stage2 Graphs for 663623 60 Cell Data for 663623 3D Structure for 663623 Basic Chemical Data for 663623
669683     rad50EPP+ rad50 mlh1 rad50EPP+ sgs1 all Stage2 Graphs for 669683 60 Cell Data for 669683 3D Structure for 669683 Basic Chemical Data for 669683
19893
5-FLUOROURACIL
    mgt1 mlh1 rad50EPP+ sgs1 mec2 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 wt2 bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 wt2 Stage2 Graphs for 19893 60 Cell Data for 19893 3D Structure for 19893 Basic Chemical Data for 19893
86005
COMPOUND A FROM NOGALAMYCIN
    rad14 rad18 rad50 mlh1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 86005 60 Cell Data for 86005 3D Structure for 86005 Basic Chemical Data for 86005
116413       bub3 rad18 mlh1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 116413   3D Structure for 116413 Basic Chemical Data for 116413
118087       rad18 rad50EPP+ rad18 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 118087 60 Cell Data for 118087   Basic Chemical Data for 118087
166024         bub3 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 166024   3D Structure for 166024 Basic Chemical Data for 166024
191250         rad18 rad50 rad52 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 191250   3D Structure for 191250 Basic Chemical Data for 191250
290721         mgt1 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 290721   3D Structure for 290721 Basic Chemical Data for 290721
290963   rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 all all all Stage2 Graphs for 290963   3D Structure for 290963 Basic Chemical Data for 290963
290979   rad50 mgt1 mlh1 rad50EPP+ sgs1 all all all Stage2 Graphs for 290979   3D Structure for 290979 Basic Chemical Data for 290979
400594     rad50EPP+ rad50EPP+ rad18 rad50 rad52 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 400594     Basic Chemical Data for 400594
403546 bub3 bub3 rad18 rad50 bub3 rad18 rad50 rad50EPP+ bub3 rad18 rad50 rad52 rad50EPP+ bub3 rad18 rad50 rad52 mlh1 rad50EPP+ Stage2 Graphs for 403546 60 Cell Data for 403546 3D Structure for 403546 Basic Chemical Data for 403546
408383   rad50EPP+ rad50EPP+ rad18 rad50 mlh1 rad50EPP+ sgs1 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 408383 60 Cell Data for 408383 3D Structure for 408383 Basic Chemical Data for 408383
622677   CLN2oe rad14 mlh1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 all all Stage2 Graphs for 622677 60 Cell Data for 622677 3D Structure for 622677 Basic Chemical Data for 622677
630510
N-METHYLTAMOXIFEN IODIDE
  rad14 rad18 rad50 mlh1 all all all Stage2 Graphs for 630510 60 Cell Data for 630510 3D Structure for 630510 Basic Chemical Data for 630510
634502   rad14 mgt1 mlh1 all all all Stage2 Graphs for 634502 60 Cell Data for 634502 3D Structure for 634502 Basic Chemical Data for 634502
637289     bub3 mec2 mlh1 sgs1 all all Stage2 Graphs for 637289 60 Cell Data for 637289 3D Structure for 637289 Basic Chemical Data for 637289
645843     rad14 mgt1 mlh1 sgs1 bub3 mec2 rad14 rad18 rad50 rad52 mgt1 mlh1 sgs1 wt2 all Stage2 Graphs for 645843 60 Cell Data for 645843 3D Structure for 645843 Basic Chemical Data for 645843
653249     rad14 rad50 mlh1 sgs1 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 CLN2oe bub3 mec2 rad14 rad18 rad50 rad52 wt1 mgt1 mlh1 sgs1 wt2 Stage2 Graphs for 653249 60 Cell Data for 653249 3D Structure for 653249 Basic Chemical Data for 653249
661224       rad50EPP+ rad18 mgt1 mlh1 rad50EPP+ Stage2 Graphs for 661224 60 Cell Data for 661224 3D Structure for 661224 Basic Chemical Data for 661224
669264     rad50 sgs1 rad50 sgs1 rad50 mgt1 mlh1 rad50EPP+ sgs1 Stage2 Graphs for 669264 60 Cell Data for 669264 3D Structure for 669264 Basic Chemical Data for 669264
670225
CIS-2((1-(4-METHYL-PHENYL)
METHYL)-4-TERT.BUTYLCYCLOHEXYL)
OXYN,N-DIMETHYL-1-
ETHANAMINE-,SALT WITH FUM
      rad14 mgt1 mlh1 sgs1 all Stage2 Graphs for 670225 60 Cell Data for 670225 3D Structure for 670225 Basic Chemical Data for 670225
672453         rad14 mgt1 mlh1 Stage2 Graphs for 672453 60 Cell Data for 672453 3D Structure for 672453 Basic Chemical Data for 672453
674560         bub3 rad14 mgt1 mlh1 Stage2 Graphs for 674560 60 Cell Data for 674560 3D Structure for 674560 Basic Chemical Data for 674560