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Developmental Therapeutics Program (DTP)
Last Updated: 08/18/15

Stage2 tested compounds that inhibit the growth of multiple yeast strains

The table below lists data for 84 compounds that inhibit the growth of multiple strains by at least 70% at the dose indicated.

These compounds inhibit the growth of a set of strains at multiple doses (i.e. inhibit rad18 AND rad50 in at least 2 of the tested doses, or inhibit mec2 AND mlh1 at multiple doses).

Compounds are listed in order by NSC number (NCI's identification number for a compound).

  • Click on Stage2 Graphs to retrieve dose-response curves and a bar graph of the IC50 values from which the IC50 value of the appropriate wild type control has been subtracted.
  • Click on 60 Cell Data to retrieve data (if available) from the 60 Human Tumor Cell Line Screen and to run COMPARE (an algorithm that finds compounds and molecular targets with similar patterns in the 60 cell screen). Not all compounds have been tested in the 60 cell line screen.
  • To retrieve structural information (if any is available) click on 3D Structure.
  • wt1 serves as the control for CLN2oe, bub3, mec2, rad14, rad18, rad50 & rad52.
  • wt2 serves as the control for mgt1, mlh1, rad50EPP+ & sgs1.

Inhibited Strains

Click here to expand the table

Email questions to: Susan Holbeck [holbecks@mail.nih.gov]