In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia resistant to Adriamycin; NSC 123127, Developed at Scr 06 & 41 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) median survival time saline 1.08 mg/kg/injection 193.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 1.8 mg/kg/injection 398.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 2.16 mg/kg/injection 495.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 3.0 mg/kg/injection 86.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 3.6 mg/kg/injection 272.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 5.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 6.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 10.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)