| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q03HX008 (ip) | survival time, mean or median | saline | 0.25 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q03HX008 (ip) | survival time, mean or median | saline | 0.5 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q03HX008 (ip) | survival time, mean or median | saline | 1.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q03HX008 (ip) | survival time, mean or median | saline | 2.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q03HX024 (ip) | survival time, mean or median | saline | 0.25 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q03HX024 (ip) | survival time, mean or median | saline | 0.5 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q03HX024 (ip) | survival time, mean or median | saline | 1.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q03HX024 (ip) | survival time, mean or median | saline | 2.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 2.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 16.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 12.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 12.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 12.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 12.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 12.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 12.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 15.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 15.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 15.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 15.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 15.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | mean survival time | saline with Tween-80 | 15.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | survival time, mean or median | saline | 2.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | survival time, mean or median | saline | 4.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | survival time, mean or median | saline | 8.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | survival time, mean or median | saline | 16.0 mg/kg/injection | NA | 06/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 1.8 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 2.7 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 2.7 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 2.7 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 2.7 mg/kg/injection | NA | 09/09 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 2.7 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 4.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 4.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 4.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 4.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 4.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 6.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 6.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 6.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | mean survival time | saline with Tween-80 | 6.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | survival time, mean or median | saline | 0.5 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | survival time, mean or median | saline | 1.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | survival time, mean or median | saline | 2.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | survival time, mean or median | saline | 4.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | survival time, mean or median | saline | 0.5 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | survival time, mean or median | saline | 1.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | survival time, mean or median | saline | 2.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | survival time, mean or median | saline | 4.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q02DX005 (ip) | median survival time | saline | 1.5 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q02DX005 (ip) | median survival time | saline | 3.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q02DX005 (ip) | median survival time | saline | 6.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q02DX005 (ip) | median survival time | saline | 12.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX002 (ip) | median survival time | saline | 2.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX002 (ip) | median survival time | saline | 4.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX002 (ip) | median survival time | saline | 8.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX002 (ip) | median survival time | saline | 16.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 12.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 13.3 mg/kg/injection | NA | 02/03 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 16.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 16.0 mg/kg/injection | NA | 04/04 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 22.0 mg/kg/injection | NA | 02/01 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 3.5 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 3.5 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 3.5 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 3.5 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 3.5 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 3.5 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 3.5 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 3.5 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 09/09 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 5.3 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 8.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 10.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 10.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | saline with Tween-80 | 10.0 mg/kg/injection | NA | 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | survival time, mean or median | saline | 2.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | survival time, mean or median | saline | 4.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | survival time, mean or median | saline | 8.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | survival time, mean or median | saline | 16.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q08DX002 (ip) | survival time, mean or median | saline | 2.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q08DX002 (ip) | survival time, mean or median | saline | 4.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q08DX002 (ip) | survival time, mean or median | saline | 8.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q08DX002 (ip) | survival time, mean or median | saline | 16.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q08DX016 (ip) | survival time, mean or median | saline | 0.25 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q08DX016 (ip) | survival time, mean or median | saline | 0.5 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q08DX016 (ip) | survival time, mean or median | saline | 1.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q08DX016 (ip) | survival time, mean or median | saline | 2.0 mg/kg/injection | NA | 08/08 animals surviving on tox evaluation day (usually day 5) |