| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX001 (ip) | median survival time | saline | 1.0 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 1.0 mg/kg/injection | 114.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 2.0 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 2.0 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 2.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 2.0 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 115.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 153.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 135.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 16.0 mg/kg/injection | 89.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 16.0 mg/kg/injection | 87.0 | Antitumor endpoint evaluated on day 60; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 16.0 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 02/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 02/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 0.03 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 0.06 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 05/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 0.12 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 04/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 0.25 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 05/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.02 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.02 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.02 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.03 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.05 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.05 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.05 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.06 mg/kg/injection | 94.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.06 mg/kg/injection | 95.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.06 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.1 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.1 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.1 mg/kg/injection | 88.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.12 mg/kg/injection | 86.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.12 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.12 mg/kg/injection | 134.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.12 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.12 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.12 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.15 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.2 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.2 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 91.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 151.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 88.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 45; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX015 (ip) | median survival time | saline | 2.0 mg/kg/injection | 176.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX015 (ip) | median survival time | saline | 3.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX015 (ip) | median survival time | saline | 3.5 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX015 (ip) | median survival time | saline | 5.3 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX015 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 05/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 0.5 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 0.5 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | 95.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.5 mg/kg/injection | 95.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 86.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.3 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.3 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.3 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 3.5 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 3.5 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 3.5 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 5.3 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 5.3 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 7.6 mg/kg/injection | 58.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 7.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 96.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 16.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 64.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 04/10 animals surviving on tox evaluation day (usually day 5) |
| Q##DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | 95.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q##DX003 (ip) | median survival time | saline | 1.5 mg/kg/injection | 95.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q##DX003 (ip) | median survival time | saline | 2.3 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q##DX003 (ip) | median survival time | saline | 3.5 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |