In Vivo Screening Data Summary

NCI In Vivo Screening Data

B16 Melanoma (intracerebral) in B6D2F1 (BDF1) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time saline 0.5 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 0.5 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 0.5 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 1.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 1.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 1.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 2.0 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 2.0 mg/kg/injection 131.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 2.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 30; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 4.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 4.0 mg/kg/injection 127.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 4.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)