| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 9.4 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 14.0 mg/kg/injection | 130.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 21.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (ip) | median survival time | saline | 1.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (ip) | median survival time | saline | 2.0 mg/kg/injection | 128.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 04/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.32 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 94.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.6 mg/kg/injection | 128.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.6 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.6 mg/kg/injection | 124.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.63 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.2 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.2 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.2 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.25 mg/kg/injection | 98.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 132.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.4 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.4 mg/kg/injection | 154.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.5 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 05/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 5.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 10.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 0.6 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 0.6 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 1.2 mg/kg/injection | 127.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 1.2 mg/kg/injection | 154.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 2.4 mg/kg/injection | 89.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 2.4 mg/kg/injection | 139.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.6 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.6 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.2 mg/kg/injection | 142.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.2 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.4 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 60; 05/05 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.4 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 3.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 4.5 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 0.6 mg/kg/injection | 39.0 | Antitumor endpoint evaluated on day 14; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 0.6 mg/kg/injection | 130.0 | Antitumor endpoint evaluated on day 18; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 1.2 mg/kg/injection | 17.0 | Antitumor endpoint evaluated on day 14; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 1.2 mg/kg/injection | 83.0 | Antitumor endpoint evaluated on day 18; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 2.4 mg/kg/injection | 75.0 | Antitumor endpoint evaluated on day 18; 05/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 0.6 mg/kg/injection | 91.0 | Antitumor endpoint evaluated on day 15; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 1.2 mg/kg/injection | 69.0 | Antitumor endpoint evaluated on day 15; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 2.4 mg/kg/injection | 25.0 | Antitumor endpoint evaluated on day 15; 05/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 4.8 mg/kg/injection | 17.0 | Antitumor endpoint evaluated on day 15; 04/06 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.25 mg/kg/injection | 86.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.25 mg/kg/injection | 95.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 139.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.5 mg/kg/injection | 90.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.5 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 152.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 139.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 114.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 33.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 144.0 | Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 10.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 10.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 4.7 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 7.0 mg/kg/injection | 124.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 10.5 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on tox evaluation day (usually day 5) |