| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q07DX002 (ip) | median tumor weight (est.) | saline | 0.5 mg/kg/injection | 173.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 0.5 mg/kg/injection | 61.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 1.0 mg/kg/injection | 230.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 1.0 mg/kg/injection | 91.0 | Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 1.0 mg/kg/injection | 71.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 1.0 mg/kg/injection | 87.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 1.0 mg/kg/injection | 40.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 1.0 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 87.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 92.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 56.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 89.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 89.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 74.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 146.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 80.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 280.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 49.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 74.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 65.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 62.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 98.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 30.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 66.0 | Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 145.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 35.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 85.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 61.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 94.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 77.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 94.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 169.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 51.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 28.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 74.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 62.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 67.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 11.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 60.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 74.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 25.0 | Antitumor endpoint evaluated on day 20; 09/09 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 39.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 14.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 36.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 46.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 36.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 55.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 18.0 | Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 57.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 19.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 28.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 57.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 17.0 | Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 34.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 05/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 02/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 57.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 11.0 | Antitumor endpoint evaluated on day 20; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 04/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 06/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 9.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 07/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 02/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 2.0 mg/kg/injection | 79.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 4.0 mg/kg/injection | 73.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 8.0 mg/kg/injection | 46.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 04/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | dextrose | 1.0 mg/kg/injection | 159.0 | Antitumor endpoint evaluated on day 20; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | dextrose | 1.0 mg/kg/injection | 86.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | dextrose | 2.0 mg/kg/injection | 90.0 | Antitumor endpoint evaluated on day 20; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | dextrose | 2.0 mg/kg/injection | 61.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | dextrose | 4.0 mg/kg/injection | 46.0 | Antitumor endpoint evaluated on day 20; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median tumor weight (est.) | dextrose | 4.0 mg/kg/injection | 42.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 0.5 mg/kg/injection | 81.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 1.0 mg/kg/injection | 124.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 1.0 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 86.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 52.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 31.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 51.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 26.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 41.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 06/10 animals surviving on tox evaluation day (usually day 5) |