| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 79.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 81.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 153.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 86.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 62.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 150.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 85.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 75.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 64.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 115.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 59.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 45.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 8.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 38.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 79.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 39.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 99.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 86.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 42.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 12.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 04/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 25.0 | Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 05/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 04/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 2.0 mg/kg/injection | 69.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 4.0 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 8.0 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20 |
| Q07DX002 (ip) | median tumor weight (est.) | suspension in saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20 |