| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX001 (ip) | median tumor weight change | saline | 1.0 mg/kg/injection | 128.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 30 |
| Q01DX001 (ip) | median tumor weight change | saline | 1.0 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 28; 09/10 animals surviving on day 28 |
| Q01DX001 (ip) | median tumor weight change | saline | 1.25 mg/kg/injection | 48.0 | Antitumor endpoint evaluated on day 33; 10/10 animals surviving on day 33 |
| Q01DX001 (ip) | median tumor weight change | saline | 1.25 mg/kg/injection | 84.0 | Antitumor endpoint evaluated on day 35; 10/10 animals surviving on day 35 |
| Q01DX001 (ip) | median tumor weight change | saline | 2.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 30 |
| Q01DX001 (ip) | median tumor weight change | saline | 2.0 mg/kg/injection | 77.0 | Antitumor endpoint evaluated on day 28; 10/10 animals surviving on day 28 |
| Q01DX001 (ip) | median tumor weight change | saline | 2.5 mg/kg/injection | 29.0 | Antitumor endpoint evaluated on day 33; 10/10 animals surviving on day 33 |
| Q01DX001 (ip) | median tumor weight change | saline | 2.5 mg/kg/injection | 62.0 | Antitumor endpoint evaluated on day 35; 10/10 animals surviving on day 35 |
| Q01DX001 (ip) | median tumor weight change | saline | 2.5 mg/kg/injection | 73.0 | Antitumor endpoint evaluated on day 34; 10/10 animals surviving on day 34 |
| Q01DX001 (ip) | median tumor weight change | saline | 4.0 mg/kg/injection | 60.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 30 |
| Q01DX001 (ip) | median tumor weight change | saline | 4.0 mg/kg/injection | 51.0 | Antitumor endpoint evaluated on day 28; 10/10 animals surviving on day 28 |
| Q01DX001 (ip) | median tumor weight change | saline | 5.0 mg/kg/injection | 30.0 | Antitumor endpoint evaluated on day 33; 10/10 animals surviving on day 33 |
| Q01DX001 (ip) | median tumor weight change | saline | 5.0 mg/kg/injection | 19.0 | Antitumor endpoint evaluated on day 35; 10/10 animals surviving on day 35 |
| Q01DX001 (ip) | median tumor weight change | saline | 5.0 mg/kg/injection | 34.0 | Antitumor endpoint evaluated on day 34; 10/10 animals surviving on day 34 |
| Q01DX001 (ip) | median tumor weight change | saline | 8.0 mg/kg/injection | -19.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 30 |
| Q01DX001 (ip) | median tumor weight change | saline | 8.0 mg/kg/injection | 18.0 | Antitumor endpoint evaluated on day 28; 10/10 animals surviving on day 28 |
| Q01DX001 (ip) | median tumor weight change | saline | 10.0 mg/kg/injection | -11.0 | Antitumor endpoint evaluated on day 33; 10/10 animals surviving on day 33 |
| Q01DX001 (ip) | median tumor weight change | saline | 10.0 mg/kg/injection | 22.0 | Antitumor endpoint evaluated on day 34; 10/10 animals surviving on day 34 |
| Q01DX001 (ip) | median tumor weight change | saline | 10.0 mg/kg/injection | -51.0 | Antitumor endpoint evaluated on day 35; 07/10 animals surviving on day 35 |
| Q01DX001 (ip) | median tumor weight change | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 33; 03/10 animals surviving on day 33 |
| Q01DX001 (ip) | median tumor weight change | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 35; 05/10 animals surviving on day 35 |
| Q01DX001 (ip) | median tumor weight change | saline with Tween-80 | 1.87 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 28; 10/10 animals surviving on day 28 |
| Q01DX001 (ip) | median tumor weight change | saline with Tween-80 | 2.5 mg/kg/injection | 74.0 | Antitumor endpoint evaluated on day 29; 10/10 animals surviving on day 29 |
| Q01DX001 (ip) | median tumor weight change | saline with Tween-80 | 3.75 mg/kg/injection | 58.0 | Antitumor endpoint evaluated on day 28; 10/10 animals surviving on day 28 |
| Q01DX001 (ip) | median tumor weight change | saline with Tween-80 | 5.0 mg/kg/injection | 19.0 | Antitumor endpoint evaluated on day 29; 10/10 animals surviving on day 29 |
| Q01DX001 (ip) | median tumor weight change | saline with Tween-80 | 7.5 mg/kg/injection | 35.0 | Antitumor endpoint evaluated on day 28; 10/10 animals surviving on day 28 |
| Q01DX001 (ip) | median tumor weight change | saline with Tween-80 | 10.0 mg/kg/injection | 5.0 | Antitumor endpoint evaluated on day 29; 09/10 animals surviving on day 29 |
| Q01DX001 (ip) | median tumor weight change | saline with Tween-80 | 15.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 28; 08/10 animals surviving on day 28 |
| Q01DX001 (ip) | median tumor weight change | saline with Tween-80 | 20.0 mg/kg/injection | -25.0 | Antitumor endpoint evaluated on day 29; 09/10 animals surviving on day 29 |
| Q01DX001 (ip) | median tumor weight change | saline with Tween-80 | 30.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 28; 03/10 animals surviving on day 28 |
| Q01DX001 (ip) | median tumor weight change | suspension in saline | 2.5 mg/kg/injection | 68.0 | Antitumor endpoint evaluated on day 36; 10/10 animals surviving on day 36 |
| Q01DX001 (ip) | median tumor weight change | suspension in saline | 5.0 mg/kg/injection | 65.0 | Antitumor endpoint evaluated on day 36; 10/10 animals surviving on day 36 |
| Q01DX001 (ip) | median tumor weight change | suspension in saline | 10.0 mg/kg/injection | 41.0 | Antitumor endpoint evaluated on day 36; 10/10 animals surviving on day 36 |
| Q01DX001 (ip) | median tumor weight change | suspension in saline | 20.0 mg/kg/injection | 7.0 | Antitumor endpoint evaluated on day 36; 08/10 animals surviving on day 36 |
| Q01DX009 (ip) | mean tumor weight | saline | 0.13 mg/kg/injection | 85.0 | Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean tumor weight | saline | 0.25 mg/kg/injection | 72.0 | Antitumor endpoint evaluated on day 31; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean tumor weight | saline | 0.25 mg/kg/injection | 73.0 | Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean tumor weight | saline | 0.5 mg/kg/injection | 4.0 | Antitumor endpoint evaluated on day 31; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean tumor weight | saline | 0.5 mg/kg/injection | 61.0 | Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean tumor weight | saline | 1.0 mg/kg/injection | 28.0 | Antitumor endpoint evaluated on day 25; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX005 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 2.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX005 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 2.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX005 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX005 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX004 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 2.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX004 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 2.0 mg/kg/injection | 9.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX004 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX004 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX004 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX004 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | saline | 1.13 mg/kg/injection | 29.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 30 |
| Q07DX005 (ip) | median tumor weight (est.) | saline | 2.0 mg/kg/injection | 29.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | saline | 2.25 mg/kg/injection | 25.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 30 |
| Q07DX005 (ip) | median tumor weight (est.) | saline | 4.0 mg/kg/injection | 18.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | saline | 4.5 mg/kg/injection | 6.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 30 |
| Q07DX005 (ip) | median tumor weight (est.) | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | saline | 9.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 03/10 animals surviving on day 30 |
| Q07DX005 (ip) | median tumor weight (est.) | saline | 18.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 03/10 animals surviving on day 30 |
| Q07DX005 (ip) | median tumor weight (est.) | suspension in saline | 1.0 mg/kg/injection | 24.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | suspension in saline | 2.0 mg/kg/injection | 18.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | suspension in saline | 4.0 mg/kg/injection | 3.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | suspension in saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | dextrose | 1.0 mg/kg/injection | 20.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | dextrose | 2.0 mg/kg/injection | 18.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX005 (ip) | median tumor weight (est.) | dextrose | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX006 (ip) | mean tumor weight | saline | 1.25 mg/kg/injection | 61.0 | Antitumor endpoint evaluated on day 37; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX006 (ip) | mean tumor weight | saline | 2.5 mg/kg/injection | 25.0 | Antitumor endpoint evaluated on day 37; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX006 (ip) | mean tumor weight | saline | 5.0 mg/kg/injection | 1.0 | Antitumor endpoint evaluated on day 37; 10/10 animals surviving on tox evaluation day (usually day 5) |