In Vivo Screening Data Summary

NCI In Vivo Screening Data

NCI-H460 Large Cell Carcinoma of the Lung (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX002 (ip) mean tumor weight change saline 2.5 mg/kg/injection 62.0 Antitumor endpoint evaluated on day 7; 06/06 animals surviving on day 7
Q04DX002 (ip) mean tumor weight change saline 2.5 mg/kg/injection 40.0 Antitumor endpoint evaluated on day 7; 06/06 animals surviving on day 7
Q04DX002 (ip) mean tumor weight change saline 5.0 mg/kg/injection 33.0 Antitumor endpoint evaluated on day 7; 06/06 animals surviving on day 7
Q04DX002 (ip) mean tumor weight change saline 5.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 7; 06/06 animals surviving on day 7
Q04DX002 (ip) mean tumor weight change saline 10.0 mg/kg/injection 16.0 Antitumor endpoint evaluated on day 7; 06/06 animals surviving on day 7
Q04DX002 (ip) mean tumor weight change saline 10.0 mg/kg/injection 10.0 Antitumor endpoint evaluated on day 7; 06/06 animals surviving on day 7
Q04DX002 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 7; 03/06 animals surviving on day 7
Q04DX002 (ip) mean tumor weight change saline 20.0 mg/kg/injection 8.0 Antitumor endpoint evaluated on day 7; 04/06 animals surviving on day 7