| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline | 6.0 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline | 6.0 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline | 10.0 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 3.5 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 5.3 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 5.3 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 1 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 6 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | 115.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 1 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 10.0 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 10.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 1 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 11.0 mg/kg/injection | 115.0 | Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 6 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 12.0 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.58 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.58 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 1 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.58 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.58 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.87 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.87 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 1 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.87 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.87 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.87 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.3 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.3 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.3 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.3 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.3 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.3 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 1 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.3 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 1 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 3.0 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 3.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 4.5 mg/kg/injection | 96.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 4.5 mg/kg/injection | 91.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 1.25 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 1.25 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 1.25 mg/kg/injection | 98.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 1.25 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 2.5 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 2.5 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 2.5 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 2.5 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 2.5 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 92.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 10.0 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 10.0 mg/kg/injection | 114.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 10.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 06/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 10.0 mg/kg/injection | 87.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 10.0 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 03/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/08 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 01/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 05/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 3.5 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 3.5 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 5.3 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 5.3 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 10.0 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline + alcohol | 1.25 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline + alcohol | 2.5 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline + alcohol | 5.0 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline + alcohol | 10.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline + alcohol | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |