| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX005 (ip) | median survival time | saline | 0.25 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 0.25 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 0.5 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 0.5 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 138.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 169.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 141.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 04/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 96.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 05/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |