| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 94.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 114.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 94.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.4 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 120.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 120.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 115.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 0.8 mg/kg/injection | 114.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 132.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 123.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 147.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 1.6 mg/kg/injection | 169.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 3.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 05/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 02/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 04/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 00/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 02/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX005 (ip) | median survival time | sodium bicarbonate | 6.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/10 animals surviving on tox evaluation day (usually day 5) |