In Vivo Screening Data Summary

NCI In Vivo Screening Data

NCI-H358 Human Lung Bronchiolo-Alveolar Carcinoma (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) mean tumor weight change saline 2.5 mg/kg/injection 13.0 Antitumor endpoint evaluated on day 16; 06/06 animals surviving on day 16
Q04DX003 (ip) mean tumor weight change saline 5.0 mg/kg/injection 67.0 Antitumor endpoint evaluated on day 16; 05/05 animals surviving on day 16
Q04DX003 (ip) mean tumor weight change saline 10.0 mg/kg/injection -12.0 Antitumor endpoint evaluated on day 16; 04/06 animals surviving on day 16
Q04DX003 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 16; 00/06 animals surviving on day 16
Q04DX004 (ip) mean tumor weight change saline 2.5 mg/kg/injection 124.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline 5.0 mg/kg/injection 46.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline 10.0 mg/kg/injection -29.0 Antitumor endpoint evaluated on day 18; 05/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 18; 00/06 animals surviving on day 18