In Vivo Screening Data Summary

NCI In Vivo Screening Data

NCI-H-69 Human Lung "Classic" SCLC (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) mean tumor weight change saline 2.5 mg/kg/injection 11.0 Antitumor endpoint evaluated on day 14; 04/05 animals surviving on day 14
Q04DX003 (ip) mean tumor weight change saline 2.5 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on day 14
Q04DX003 (ip) mean tumor weight change saline 5.0 mg/kg/injection -43.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on day 14
Q04DX003 (ip) mean tumor weight change saline 5.0 mg/kg/injection 8.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on day 14
Q04DX003 (ip) mean tumor weight change saline 10.0 mg/kg/injection -64.0 Antitumor endpoint evaluated on day 14; 04/06 animals surviving on day 14
Q04DX003 (ip) mean tumor weight change saline 10.0 mg/kg/injection -30.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on day 14
Q04DX003 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 00/06 animals surviving on day 14
Q04DX003 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 00/06 animals surviving on day 14