In Vivo Screening Data Summary

NCI In Vivo Screening Data

DLD-1 Human Colon Tumor (subcutaneous) in NU/NU BALB/C (nude) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) median tumor weight change saline 2.5 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 26; 06/06 animals surviving on day 21
Q04DX003 (ip) median tumor weight change saline 5.0 mg/kg/injection 31.0 Antitumor endpoint evaluated on day 26; 06/06 animals surviving on day 21
Q04DX003 (ip) median tumor weight change saline 10.0 mg/kg/injection 30.0 Antitumor endpoint evaluated on day 26; 06/06 animals surviving on day 21
Q04DX003 (ip) median tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 26; 02/06 animals surviving on day 21