In Vivo Screening Data Summary

NCI In Vivo Screening Data

MCF-7-Breast Adenocarcinoma/ADR resistant (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX004 (ip) mean tumor weight change saline 2.5 mg/kg/injection 65.0 Antitumor endpoint evaluated on day 19; 06/06 animals surviving on day 19
Q04DX004 (ip) mean tumor weight change saline 5.0 mg/kg/injection 74.0 Antitumor endpoint evaluated on day 19; 06/06 animals surviving on day 19
Q04DX004 (ip) mean tumor weight change saline 5.0 mg/kg/injection 32.0 Antitumor endpoint evaluated on day 19; 05/06 animals surviving on day 19
Q04DX004 (ip) mean tumor weight change saline 10.0 mg/kg/injection 10.0 Antitumor endpoint evaluated on day 19; 05/06 animals surviving on day 19
Q04DX004 (ip) mean tumor weight change saline 10.0 mg/kg/injection 12.0 Antitumor endpoint evaluated on day 19; 06/06 animals surviving on day 19
Q04DX004 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 19; 00/06 animals surviving on day 19
Q04DX004 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 19; 00/06 animals surviving on day 19