| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX001 (ip) | median survival time | water | 5.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | water | 5.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | water | 10.0 mg/kg/injection | 88.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | water | 10.0 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | water | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | water | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (sc) | median survival time | saline | 1.8 mg/kg/injection | 120.0 | Antitumor endpoint evaluated on day 40; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (sc) | median survival time | saline | 3.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (sc) | median survival time | saline | 3.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 40; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (sc) | median survival time | saline | 5.0 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (sc) | median survival time | saline | 5.0 mg/kg/injection | 130.0 | Antitumor endpoint evaluated on day 40; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (sc) | median survival time | saline | 8.4 mg/kg/injection | 136.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (sc) | median survival time | saline | 8.4 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 40; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (sc) | median survival time | saline | 14.0 mg/kg/injection | 151.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (sc) | median survival time | saline | 14.0 mg/kg/injection | 150.0 | Antitumor endpoint evaluated on day 40; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | water | 1.25 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | water | 1.25 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | water | 2.5 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | water | 2.5 mg/kg/injection | 88.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | water | 5.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | water | 5.0 mg/kg/injection | 88.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 1.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 99.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 3.0 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 3.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 31; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 120.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 134.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 127.0 | Antitumor endpoint evaluated on day 31; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 178.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 175.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 130.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 138.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.4 mg/kg/injection | 169.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 8.4 mg/kg/injection | 166.0 | Antitumor endpoint evaluated on day 31; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 14.0 mg/kg/injection | 146.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 14.0 mg/kg/injection | 133.0 | Antitumor endpoint evaluated on day 31; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 16.0 mg/kg/injection | 141.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 16.0 mg/kg/injection | 168.0 | Antitumor endpoint evaluated on day 5; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 16.0 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 16.0 mg/kg/injection | 160.0 | Antitumor endpoint evaluated on day 33; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | water | 5.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | water | 5.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | water | 10.0 mg/kg/injection | 88.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | water | 10.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | water | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | water | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (sc) | median survival time | saline | 3.0 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (sc) | median survival time | saline | 5.0 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (sc) | median survival time | saline | 5.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 40; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (sc) | median survival time | saline | 8.4 mg/kg/injection | 171.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (sc) | median survival time | saline | 8.4 mg/kg/injection | 120.0 | Antitumor endpoint evaluated on day 40; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (sc) | median survival time | saline | 14.0 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q07DX003 (sc) | median survival time | saline | 14.0 mg/kg/injection | 170.0 | Antitumor endpoint evaluated on day 40; 08/08 animals surviving on tox evaluation day (usually day 5) |