| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX001 (ip) | median survival time | saline | 2.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 2.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 36; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 36; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 36; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 16.0 mg/kg/injection | 21.0 | Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 36; 00/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (sc) | median survival time | saline | 0.88 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 14; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (sc) | median survival time | saline | 0.88 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 62; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (sc) | median survival time | saline | 1.5 mg/kg/injection | 138.0 | Antitumor endpoint evaluated on day 14; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (sc) | median survival time | saline | 1.5 mg/kg/injection | 134.0 | Antitumor endpoint evaluated on day 62; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (sc) | median survival time | saline | 2.5 mg/kg/injection | 75.0 | Antitumor endpoint evaluated on day 14; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (sc) | median survival time | saline | 2.5 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 62; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (sc) | median survival time | saline | 4.1 mg/kg/injection | 55.0 | Antitumor endpoint evaluated on day 14; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX007 (sc) | median survival time | saline | 4.1 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 62; 00/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 0.3 mg/kg/injection | 98.0 | Antitumor endpoint evaluated on day 42; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 0.6 mg/kg/injection | 88.0 | Antitumor endpoint evaluated on day 42; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 1.2 mg/kg/injection | 96.0 | Antitumor endpoint evaluated on day 42; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 2.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 42; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 42; 00/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 9.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 42; 00/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 0.3 mg/kg/injection | 91.0 | Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 0.6 mg/kg/injection | 48.0 | Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 1.2 mg/kg/injection | 66.0 | Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 2.4 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5) |