| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX009 (ip) | median survival time | saline | 0.2 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.2 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.4 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q01DX009 (ip) | median survival time | saline | 0.4 mg/kg/injection | 300.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.4 mg/kg/injection | 134.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.4 mg/kg/injection | 142.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.4 mg/kg/injection | 141.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.4 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.4 mg/kg/injection | 128.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.8 mg/kg/injection | 132.0 | Antitumor endpoint evaluated on day 48; 05/06 animals surviving on day 9 |
| Q01DX009 (ip) | median survival time | saline | 0.8 mg/kg/injection | 145.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.8 mg/kg/injection | 271.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.8 mg/kg/injection | 214.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.8 mg/kg/injection | 291.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.8 mg/kg/injection | 346.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.8 mg/kg/injection | 207.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.8 mg/kg/injection | 167.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.6 mg/kg/injection | 187.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q01DX009 (ip) | median survival time | saline | 1.6 mg/kg/injection | 346.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.6 mg/kg/injection | 338.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.6 mg/kg/injection | 319.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.6 mg/kg/injection | 560.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.6 mg/kg/injection | 372.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.6 mg/kg/injection | 346.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.6 mg/kg/injection | 319.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 2.4 mg/kg/injection | 210.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q01DX009 (ip) | median survival time | saline | 2.4 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 2.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (sc) | median survival time | saline | 0.5 mg/kg/injection | 94.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (sc) | median survival time | saline | 1.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (sc) | median survival time | saline | 2.0 mg/kg/injection | 153.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (sc) | median survival time | saline | 3.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 151.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q04DX003 (ip) | median survival time | saline | 2.0 mg/kg/injection | 160.0 | Antitumor endpoint evaluated on day 64; 10/10 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 164.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 226.0 | Antitumor endpoint evaluated on day 64; 10/10 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline | 6.0 mg/kg/injection | 226.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q04DX003 (ip) | median survival time | saline | 6.0 mg/kg/injection | 331.0 | Antitumor endpoint evaluated on day 64; 10/10 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline | 8.0 mg/kg/injection | 139.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q04DX003 (iv) | median survival time | saline | 2.0 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q04DX003 (iv) | median survival time | saline | 4.0 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q04DX003 (iv) | median survival time | saline | 6.0 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |
| Q04DX003 (iv) | median survival time | saline | 8.0 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 48; 06/06 animals surviving on day 9 |