| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX009 (ip) | median survival time | saline | 0.12 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.12 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.13 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 98.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 99.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 120.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 151.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 127.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 176.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 150.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 157.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.12 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.25 mg/kg/injection | 103.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.5 mg/kg/injection | 96.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.0 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5 |