| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX001 (ip) | median survival time | saline | 1.0 mg/kg/injection | 92.0 | Antitumor endpoint evaluated on day 80; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 2.0 mg/kg/injection | 90.0 | Antitumor endpoint evaluated on day 80; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 4.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 80; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 8.0 mg/kg/injection | 136.0 | Antitumor endpoint evaluated on day 80; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (ip) | median survival time | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 80; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.06 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.12 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 134.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.25 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.5 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.6 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 0.8 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 10 |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 142.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.2 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.6 mg/kg/injection | 123.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 10 |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 135.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 98.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.4 mg/kg/injection | 137.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 10 |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 0.6 mg/kg/injection | 123.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 0.6 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 1.2 mg/kg/injection | 94.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 1.2 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 2.4 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 2.4 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.6 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 0.6 mg/kg/injection | 86.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.2 mg/kg/injection | 143.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 1.2 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.4 mg/kg/injection | 91.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.4 mg/kg/injection | 91.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 4.8 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 0.6 mg/kg/injection | 98.0 | Antitumor endpoint evaluated on day 18; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 1.2 mg/kg/injection | 50.0 | Antitumor endpoint evaluated on day 18; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 2.4 mg/kg/injection | 29.0 | Antitumor endpoint evaluated on day 18; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | Klucel (hydroxypropylcellulose) (HPC) | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 18; 03/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 0.6 mg/kg/injection | 87.0 | Antitumor endpoint evaluated on day 18; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 1.2 mg/kg/injection | 80.0 | Antitumor endpoint evaluated on day 18; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 2.4 mg/kg/injection | 37.0 | Antitumor endpoint evaluated on day 18; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 4.8 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 18; 01/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 0.25 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 0.5 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 1.0 mg/kg/injection | 147.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 2.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 4.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 0.3 mg/kg/injection | 73.0 | Antitumor endpoint evaluated on day 12; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 0.6 mg/kg/injection | 43.0 | Antitumor endpoint evaluated on day 12; 05/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 1.2 mg/kg/injection | 13.0 | Antitumor endpoint evaluated on day 12; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 3.0 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline | 3.0 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 128.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline | 4.0 mg/kg/injection | 146.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline | 6.0 mg/kg/injection | 120.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline | 6.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 10 |