In Vivo Screening Data Summary

NCI In Vivo Screening Data

A549 Human Adenocarcinoma of Lung with characteristics of Type II Alveolar Epithelial cells (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) mean tumor weight change saline 2.5 mg/kg/injection 66.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 2.5 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 2.5 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 2.5 mg/kg/injection 80.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 5.0 mg/kg/injection 57.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 5.0 mg/kg/injection 32.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 5.0 mg/kg/injection 24.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 5.0 mg/kg/injection 24.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 10.0 mg/kg/injection 34.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 10.0 mg/kg/injection 9.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 10.0 mg/kg/injection 6.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 10.0 mg/kg/injection -43.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 01/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 02/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 02/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 00/06 animals surviving on day 12