In Vivo Screening Data Summary

NCI In Vivo Screening Data

Human Amelanotic Melanoma (LOX) (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q02DX002 (ip) mean tumor weight change saline 2.5 mg/kg/injection 51.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change saline 2.5 mg/kg/injection 39.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change saline 5.0 mg/kg/injection 26.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change saline 5.0 mg/kg/injection 24.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change saline 10.0 mg/kg/injection 9.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change saline 10.0 mg/kg/injection 13.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 6; 02/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 6; 04/06 animals surviving on day 6