| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 157.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 4.0 mg/kg/injection | 164.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | 198.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 16.0 mg/kg/injection | 341.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX001 (ip) | median survival time | saline with Tween-80 | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 03/06 animals surviving on day 10 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 0.5 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 1.0 mg/kg/injection | 160.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 258.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 4.0 mg/kg/injection | 300.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 00/06 animals surviving on day 10 |
| Q01DX015 (ip) | median survival time | saline with Tween-80 | 0.25 mg/kg/injection | 135.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX015 (ip) | median survival time | saline with Tween-80 | 0.5 mg/kg/injection | 164.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX015 (ip) | median survival time | saline with Tween-80 | 1.0 mg/kg/injection | 252.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX015 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 247.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q01DX015 (ip) | median survival time | saline with Tween-80 | 4.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline | 2.5 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 75; 06/06 animals surviving on day 14 |
| Q04DX003 (ip) | median survival time | saline | 5.0 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 75; 06/06 animals surviving on day 14 |
| Q04DX003 (ip) | median survival time | saline | 10.0 mg/kg/injection | 271.0 | Antitumor endpoint evaluated on day 75; 06/06 animals surviving on day 14 |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 94.0 | Antitumor endpoint evaluated on day 75; 06/06 animals surviving on day 14 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 1.0 mg/kg/injection | 158.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 181.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 4.0 mg/kg/injection | 247.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 8.0 mg/kg/injection | 352.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q04DX003 (ip) | median survival time | saline with Tween-80 | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 03/06 animals surviving on day 10 |
| Q04DX003 (iv) | median survival time | saline | 2.5 mg/kg/injection | 138.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q04DX003 (iv) | median survival time | saline | 5.0 mg/kg/injection | 156.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q04DX003 (iv) | median survival time | saline | 10.0 mg/kg/injection | 176.0 | Antitumor endpoint evaluated on day 60; 06/06 animals surviving on day 10 |
| Q04DX003 (iv) | median survival time | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 00/06 animals surviving on day 10 |