In Vivo Screening Data Summary

NCI In Vivo Screening Data

Human Amelanotic Melanoma (LOX) (subcutaneous) in NU/NU BALB/C (nude) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) optimum tumor weight change saline 9.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 43; 01/10 animals surviving on day 28
Q01DX001 (ip) optimum tumor weight change saline 15.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 43; 04/10 animals surviving on day 28
Q01DX001 (ip) optimum tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 43; 00/10 animals surviving on day 28
Q01DX001 (ip) optimum tumor weight change saline 25.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 43; 00/10 animals surviving on day 28
Q01DX001 (ip) optimum tumor weight change saline 25.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 26; 02/09 animals surviving on day 27
Q01DX001 (ip) optimum tumor weight change saline 30.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 26; 00/09 animals surviving on day 27
Q01DX001 (ip) optimum tumor weight change saline 35.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 26; 00/09 animals surviving on day 27
Q01DX001 (ip) optimum tumor weight change saline 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 26; 00/09 animals surviving on day 27
Q01DX001 (ip) optimum tumor weight change saline 45.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 26; 00/09 animals surviving on day 27