| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 143.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 123.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 139.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 186.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 158.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 150.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 156.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 226.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 204.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 170.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 183.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 261.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 228.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 09/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 0.5 mg/kg/injection | 152.0 | Antitumor endpoint evaluated on day 100; 08/08 animals surviving on day 17 |
| Q04DX005 (ip) | median survival time | saline | 0.52 mg/kg/injection | 143.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 0.86 mg/kg/injection | 145.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 167.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 130.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 5 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 176.0 | Antitumor endpoint evaluated on day 100; 08/08 animals surviving on day 17 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 153.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 1.44 mg/kg/injection | 162.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 208.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 191.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 5 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 168.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 154.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 165.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 244.0 | Antitumor endpoint evaluated on day 100; 08/08 animals surviving on day 17 |
| Q04DX005 (ip) | median survival time | saline | 2.4 mg/kg/injection | 186.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 292.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 321.0 | Antitumor endpoint evaluated on day 100; 08/08 animals surviving on day 17 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 307.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 5 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 228.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 164.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 217.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 242.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 6.67 mg/kg/injection | 254.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 261.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 09/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 09/09 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 5 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 87.0 | Antitumor endpoint evaluated on day 100; 06/08 animals surviving on day 17 |