| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q04DX004 (ip) | median survival time | saline | 0.25 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 0.5 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 0.5 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 134.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 136.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 128.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 153.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 137.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 1.0 mg/kg/injection | 137.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 150.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 180.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 178.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 185.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 135.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 176.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 147.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 136.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 137.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 159.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 153.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 2.0 mg/kg/injection | 183.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 211.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 309.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 233.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 205.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 189.0 | Antitumor endpoint evaluated on day 75; 09/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 157.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 162.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 201.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 152.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 234.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 213.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 198.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 4.0 mg/kg/injection | 215.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 323.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 202.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 285.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 256.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 87.0 | Antitumor endpoint evaluated on day 60; 08/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 07/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 283.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 8.0 mg/kg/injection | 265.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 16.0 mg/kg/injection | 265.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 14 |
| Q04DX004 (ip) | median survival time | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 00/10 animals surviving on day 14 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 143.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 128.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 1.0 mg/kg/injection | 133.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 189.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 155.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 145.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.0 mg/kg/injection | 152.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 201.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 188.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 206.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 195.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 08/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 8.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 75; 09/10 animals surviving on day 9 |