| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 2.0 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 62; 10/10 animals surviving on day 62 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 3.0 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 62; 10/10 animals surviving on day 62 |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 4.5 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 62; 00/10 animals surviving on day 62 |
| Q02DX030 (ip) | median survival time | saline | 0.63 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 100; 09/09 animals surviving on day 16 |
| Q02DX030 (ip) | median survival time | saline | 0.63 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q02DX030 (ip) | median survival time | saline | 1.25 mg/kg/injection | 161.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q02DX030 (ip) | median survival time | saline | 1.25 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q02DX030 (ip) | median survival time | saline | 2.5 mg/kg/injection | 288.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q02DX030 (ip) | median survival time | saline | 2.5 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 100; 08/10 animals surviving on day 16 |
| Q02DX030 (ip) | median survival time | saline | 5.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q02DX030 (ip) | median survival time | saline | 5.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q02DX032 (ip) | median survival time | saline | 0.63 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q02DX032 (ip) | median survival time | saline | 1.25 mg/kg/injection | 161.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q02DX032 (ip) | median survival time | saline | 2.5 mg/kg/injection | 128.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q02DX032 (ip) | median survival time | saline | 5.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 100; 10/10 animals surviving on day 16 |
| Q04DX005 (ip) | median survival time | saline | 0.52 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 0.86 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 1.44 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 2.4 mg/kg/injection | 156.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 4.0 mg/kg/injection | 187.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median survival time | saline | 6.67 mg/kg/injection | 209.0 | Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9 |
| Q04DX005 (ip) | median tumor weight (est.) | saline | 0.52 mg/kg/injection | 59.0 | Antitumor endpoint evaluated on day 22; 10/10 animals surviving on day 22 |
| Q04DX005 (ip) | median tumor weight (est.) | saline | 0.86 mg/kg/injection | 50.0 | Antitumor endpoint evaluated on day 22; 10/10 animals surviving on day 22 |
| Q04DX005 (ip) | median tumor weight (est.) | saline | 1.44 mg/kg/injection | 42.0 | Antitumor endpoint evaluated on day 22; 10/10 animals surviving on day 22 |
| Q04DX005 (ip) | median tumor weight (est.) | saline | 2.4 mg/kg/injection | 5.0 | Antitumor endpoint evaluated on day 22; 10/10 animals surviving on day 22 |
| Q04DX005 (ip) | median tumor weight (est.) | saline | 6.67 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 22; 05/10 animals surviving on day 22 |
| Q07DX002 (ip) | median survival time | saline | 3.97 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 36; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median survival time | saline | 5.94 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 36; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median survival time | saline | 8.89 mg/kg/injection | 139.0 | Antitumor endpoint evaluated on day 36; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (ip) | median survival time | saline | 13.3 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 36; 06/08 animals surviving on tox evaluation day (usually day 5) |