In Vivo Screening Data Summary

NCI In Vivo Screening Data

M5076 resistant to Cisplatin II; NSC 119875 (subcutaneous) in B6D2F1 (BDF1) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX005 (ip) median survival time saline 0.52 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9
Q04DX005 (ip) median survival time saline 0.86 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9
Q04DX005 (ip) median survival time saline 1.44 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9
Q04DX005 (ip) median survival time saline 2.4 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9
Q04DX005 (ip) median survival time saline 4.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9
Q04DX005 (ip) median survival time saline 6.67 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 90; 10/10 animals surviving on day 9