In Vivo Screening Data Summary

NCI In Vivo Screening Data

TE-671 Human Meduloblastoma (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 119875
CAS 15663-27-1
Cisplatin; Plantinol AQ; Cis-DDP

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) mean tumor weight change saline 2.5 mg/kg/injection 64.0 Antitumor endpoint evaluated on day 10; 05/06 animals surviving on day 10
Q04DX003 (ip) mean tumor weight change saline 2.5 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 5.0 mg/kg/injection 40.0 Antitumor endpoint evaluated on day 10; 06/06 animals surviving on day 10
Q04DX003 (ip) mean tumor weight change saline 5.0 mg/kg/injection 36.0 Antitumor endpoint evaluated on day 12; 04/05 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 10.0 mg/kg/injection -48.0 Antitumor endpoint evaluated on day 10; 06/06 animals surviving on day 10
Q04DX003 (ip) mean tumor weight change saline 10.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 10; 00/06 animals surviving on day 10
Q04DX003 (ip) mean tumor weight change saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 02/06 animals surviving on day 12