In Vivo Screening Data Summary

NCI In Vivo Screening Data

Adenocarcinoma 755 (subcutaneous) in C57BL/6 mice

NSC 29420
CAS 1198-47-6
6-Methylthioguanine; 2-Amino-6-methylthiopurine; 2-Amino-6-methylmercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (ip) mean tumor weight saline 10.0 mg/kg/injection 1.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 15.0 mg/kg/injection 1.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5)