| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX005 (ip) | median survival time | saline | 25.0 mg/kg/injection | 119.0 | Antitumor endpoint evaluated on day 30; 05/06 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline | 25.0 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline | 50.0 mg/kg/injection | 130.0 | Antitumor endpoint evaluated on day 30; 05/06 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline | 50.0 mg/kg/injection | 146.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline | 100.0 mg/kg/injection | 164.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline | 100.0 mg/kg/injection | 217.0 | Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline | 200.0 mg/kg/injection | 225.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline | 200.0 mg/kg/injection | 87.0 | Antitumor endpoint evaluated on day 30; 09/10 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline | 400.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 02/10 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 25.0 mg/kg/injection | 118.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 50.0 mg/kg/injection | 145.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 100.0 mg/kg/injection | 189.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 200.0 mg/kg/injection | 254.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5 |
| Q01DX005 (ip) | median survival time | saline with Tween-80 | 400.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 03/06 animals surviving on day 5 |