| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX010 (ip) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 25.0 mg/kg/injection | 164.0 | Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11 |
| Q01DX010 (ip) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 50.0 mg/kg/injection | 130.0 | Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11 |
| Q01DX010 (ip) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 100.0 mg/kg/injection | 61.0 | Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11 |
| Q01DX010 (ip) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 200.0 mg/kg/injection | 40.0 | Antitumor endpoint evaluated on day 11; 02/03 animals surviving on day 11 |
| Q01DX010 (sc) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 50.0 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 11; 02/02 animals surviving on day 11 |
| Q01DX010 (sc) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 100.0 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 11; 02/02 animals surviving on day 11 |
| Q01DX010 (sc) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 200.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11 |
| Q01DX010 (sc) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 400.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11 |
| Q04DX003 (ip) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 83.0 mg/kg/injection | 129.0 | Antitumor endpoint evaluated on day 11; 02/02 animals surviving on day 11 |
| Q04DX003 (ip) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 166.66 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 11; 01/01 animals surviving on day 11 |
| Q04DX003 (ip) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 333.33 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 11; 01/03 animals surviving on day 11 |
| Q04DX003 (ip) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 666.65 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11 |
| Q04DX003 (sc) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 166.6 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 11; 02/02 animals surviving on day 11 |
| Q04DX003 (sc) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 333.3 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11 |
| Q04DX003 (sc) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 666.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11 |
| Q04DX003 (sc) | mean tumor weight change | Klucel (hydroxypropylcellulose) (HPC) | 1333.3 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11 |