In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 5992
CAS 1096-84-0
2-Naphthalenol, 1,1'-methylenebis-

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) mean survival time saline 50.0 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time saline 100.0 mg/kg/injection 86.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time saline 200.0 mg/kg/injection 86.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time saline with Tween-80 50.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time saline with Tween-80 100.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time saline with Tween-80 200.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) mean survival time saline 100.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) mean survival time saline 200.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) mean survival time saline 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)