In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia (subcutaneous) in B6D2F1 (BDF1) mice

NSC 71261
CAS 789-61-7
BTG; NSC 71261; .beta.-TGdR

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q02DX005 (sc) median survival time saline 9.0 mg/kg/injection 160.0 Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 9.0 mg/kg/injection 160.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 12.5 mg/kg/injection 177.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 18.0 mg/kg/injection 162.0 Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 18.0 mg/kg/injection 162.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 25.0 mg/kg/injection 177.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 37.0 mg/kg/injection 152.0 Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 37.0 mg/kg/injection 152.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 50.0 mg/kg/injection 177.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 75.0 mg/kg/injection 161.0 Antitumor endpoint evaluated on day 7; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 75.0 mg/kg/injection 161.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (sc) median survival time saline 100.0 mg/kg/injection 150.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)