In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice

NSC 86139
CAS 6439-85-6
Pyrimido[5,4-g]pteridine-2,4,6,8(1H,3H,7H,9H)-tetrone, 1,3,7,9-tetramethyl-

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 6.25 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 6.25 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 6.25 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 120.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 126.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 30; 04/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 129.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on day 5