In Vivo Screening Data Summary

NCI In Vivo Screening Data

C3H Mammary Adenocarcinoma 16/C (subcutaneous) in B6C3F1 mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) optimum tumor weight change saline 26.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 35; 00/08 animals surviving on day 31
Q01DX005 (ip) optimum tumor weight change saline 32.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 35; 00/08 animals surviving on day 31
Q01DX005 (ip) optimum tumor weight change saline 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 35; 00/08 animals surviving on day 31
Q01DX005 (ip) optimum tumor weight change saline 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 35; 01/08 animals surviving on day 31
Q07DX002 (ip) median tumor weight (est.) saline 8.0 mg/kg/injection 145.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) saline 16.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) saline 32.0 mg/kg/injection 13.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) saline 64.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) saline 128.0 mg/kg/injection 1.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) saline 256.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) suspension in saline 8.0 mg/kg/injection 85.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) suspension in saline 16.0 mg/kg/injection 144.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) suspension in saline 32.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) suspension in saline 64.0 mg/kg/injection 61.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) suspension in saline 128.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) suspension in saline 256.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 07/10 animals surviving on tox evaluation day (usually day 5)