In Vivo Screening Data Summary

NCI In Vivo Screening Data

C3H Mammary Adenocarcinoma 16/C (subcutaneous) in B6C3F1 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 8.0 mg/kg/injection 68.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 16.0 mg/kg/injection 64.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 32.0 mg/kg/injection 122.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 64.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 128.0 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 256.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 14; 08/10 animals surviving on tox evaluation day (usually day 5)