In Vivo Screening Data Summary

NCI In Vivo Screening Data

Carcinoma 1025 (subcutaneous) in C3AKF1 (CHKRF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.5 mg/kg/injection 69.0 Antitumor endpoint evaluated on day 15; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.5 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 15; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.5 mg/kg/injection 61.0 Antitumor endpoint evaluated on day 15; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.5 mg/kg/injection 73.0 Antitumor endpoint evaluated on day 15; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 25.0 mg/kg/injection 37.0 Antitumor endpoint evaluated on day 15; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 25.0 mg/kg/injection 51.0 Antitumor endpoint evaluated on day 15; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 25.0 mg/kg/injection 41.0 Antitumor endpoint evaluated on day 15; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 25.0 mg/kg/injection 51.0 Antitumor endpoint evaluated on day 15; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 50.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 15; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 50.0 mg/kg/injection 35.0 Antitumor endpoint evaluated on day 15; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 50.0 mg/kg/injection 17.0 Antitumor endpoint evaluated on day 15; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 50.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 15; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 100.0 mg/kg/injection 8.0 Antitumor endpoint evaluated on day 15; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 15; 06/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 15; 04/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight carboxymethylcellulose (CMC) 100.0 mg/kg/injection 15.0 Antitumor endpoint evaluated on day 15; 07/10 animals surviving on tox evaluation day (usually day 5)