In Vivo Screening Data Summary

NCI In Vivo Screening Data

P288 Lymphocytic Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 5.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 5.0 mg/kg/injection 92.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 10.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 10.0 mg/kg/injection 94.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 20.0 mg/kg/injection 86.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 20.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 40.0 mg/kg/injection 86.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 40.0 mg/kg/injection 110.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 80.0 mg/kg/injection 86.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median alkali diluted with saline 80.0 mg/kg/injection 117.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 12.5 mg/kg/injection 97.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 25.0 mg/kg/injection 93.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 25.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 50.0 mg/kg/injection 94.0 Experiment continued until the death of all animals; 04/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 50.0 mg/kg/injection 102.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 100.0 mg/kg/injection 118.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 100.0 mg/kg/injection 126.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 100.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 200.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 200.0 mg/kg/injection 106.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) survival time, mean or median other 400.0 mg/kg/injection 89.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)