In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia resistant to Tiazofurin; NSC 286193, Developed at LMCB,DTP,DCT,NCI (intraperitoneal) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 25.0 mg/kg/injection 163.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 357.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 432.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 357.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 100.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 160.0 mg/kg/injection 357.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 45; 01/06 animals surviving on day 5