In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia resistant to Adriamycin; NSC 123127, Developed at Scr 06 & 41 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time alkali diluted with saline 43.2 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 72.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/08 animals surviving on tox evaluation day (usually day 5)