In Vivo Screening Data Summary

NCI In Vivo Screening Data

P335 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX Z (ip) mean survival time other 37.5 mg/kg/injection 116.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 75.0 mg/kg/injection 114.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 150.0 mg/kg/injection 137.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 300.0 mg/kg/injection 122.0 Experiment continued until the death of all animals; 05/06 animals surviving on tox evaluation day (usually day 5)