In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to 6-MP & 6-MMPR & 7-Thioguanine; NSC 755, NSC 40774, NSC 752 (intraperitoneal) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) mean survival time alkali diluted with water 20.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 40.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 80.0 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 160.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 30; 04/06 animals surviving on tox evaluation day (usually day 5)