In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to 6-Thioguanine; NSC 752 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 9.2 mg/kg/injection 97.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 9.24 mg/kg/injection 87.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 14.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 14.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 21.0 mg/kg/injection 97.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 21.5 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 31.5 mg/kg/injection 104.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 31.5 mg/kg/injection 96.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 47.25 mg/kg/injection 95.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 47.25 mg/kg/injection 98.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)